ISO 45855 Macrolide Profiling in Dairy-Based Foods
The ISO 45855 standard provides a robust framework for the qualitative and quantitative determination of macrolides in dairy-based foods. This service is essential for ensuring that food products meet regulatory standards regarding veterinary drug residues, thereby protecting public health and maintaining consumer trust.
Macrolides are a class of antibiotics commonly used in animal husbandry to treat bacterial infections and promote growth. However, their presence at levels exceeding legal limits can pose significant risks to human health through the consumption of contaminated dairy products such as milk, cheese, yogurt, and butter. Regulatory bodies like the European Commission (EC) have established maximum residue limits (MRLs) for macrolides in these foodstuffs.
Our ISO 45855 Macrolide Profiling service utilizes advanced analytical techniques to detect trace amounts of macrolides in dairy-based foods, ensuring compliance with MRLs set by international standards. This includes testing for drugs like erythromycin, clarithromycin, and azithromycin among others, which are frequently used in veterinary medicine.
The importance of this service extends beyond mere compliance; it also contributes to the reputation of food producers who can demonstrate their commitment to maintaining high-quality standards. By leveraging our expertise, clients gain access to accurate, reliable results that support informed decision-making throughout the supply chain.
To achieve optimal performance in macrolide profiling, proper sample preparation is crucial. This involves careful selection and processing of dairy samples to minimize potential interferences from other components present in raw materials or during storage. Samples are typically homogenized before extraction using organic solvents followed by purification steps such as solid-phase extraction (SPE). The resulting extracts undergo chromatographic separation techniques like liquid chromatography-tandem mass spectrometry (LC-MS/MS), which enable precise identification and quantification of target compounds.
Our lab adheres strictly to the ISO 45855 protocol, ensuring consistent results across all tests conducted. This includes rigorous quality control measures at every stage from sample receipt through final analysis and reporting. Our highly trained technicians employ state-of-the-art equipment including high-performance liquid chromatographs coupled with triple quadrupole mass spectrometers (HPLC-QQQ), enabling detection limits down to parts per billion (ppb).
In summary, our ISO 45855 Macrolide Profiling service offers comprehensive analysis of macrolides in dairy-based foods. By adhering strictly to international standards and utilizing advanced technologies, we provide accurate, reliable results that contribute significantly towards maintaining food safety and quality.
Scope and Methodology
| Methodological Steps | Description |
|---|---|
| Sampling | Select representative samples from various batches of dairy products ensuring they reflect the entire production batch. |
| Preliminary Screening | Conduct initial tests to identify potential macrolide contamination using rapid immunoassay kits or other screening methods. |
| Extraction and Purification | Use appropriate solvents followed by solid-phase extraction techniques to remove interfering substances and concentrate the target analytes. |
| Chromatographic Separation | Perform liquid chromatography (LC) using reversed phase columns packed with C18 stationary phases. Mobile phases consist of acetonitrile-water mixtures adjusted according to specific conditions outlined in ISO 45855. |
| Detection and Quantification | Implement mass spectrometry (MS) equipped with electrospray ionization (ESI) source interfaced directly with the LC system. Employ multiple reaction monitoring mode (MRM) to enhance selectivity and sensitivity allowing accurate quantitation of macrolides down to ppb levels. |
| Validation | Ensure all analytical procedures comply with ISO 45855 requirements including linearity, precision, accuracy, robustness, specificity, and matrix effects correction. |
The above table outlines the key steps involved in performing macrolide profiling according to ISO 45855. Each step plays a vital role in ensuring accurate detection and quantification of macrolides within dairy-based foods.
International Acceptance and Recognition
- The ISO 45855 standard is widely recognized by regulatory bodies across the globe including the European Union, United States Food and Drug Administration (FDA), World Health Organization (WHO), and others. It serves as a benchmark for harmonization of analytical methods used globally.
- Countries implementing this standard benefit from increased confidence in international trade agreements related to food safety due to consistent testing protocols that ensure uniformity among exporting nations.
These points highlight why adherence to ISO 45855 is crucial not only for compliance but also for enhancing market access opportunities internationally. Compliance with these standards demonstrates a company's commitment to quality and safety which can be leveraged in marketing strategies aimed at attracting discerning consumers seeking assurance about the products they purchase.
Competitive Advantage and Market Impact
- Pioneering use of advanced analytical techniques allows early detection of even minute traces of macrolides, giving businesses a competitive edge over competitors lacking similar capabilities.
- Proactive approach to monitoring ensures continuous improvement in product quality, potentially leading to reduced recalls and associated costs while enhancing brand reputation through transparent communication with consumers about rigorous testing processes employed.
The ability to consistently meet or exceed regulatory requirements fosters trust between producers and regulators alike. This builds long-term relationships that are beneficial for both parties involved. Moreover, being first to market with innovative solutions can significantly impact consumer perception favorably towards your brand.
